Baby Eye Color Calculator

CalculateQuick

·

·

This explorer shows documented observations from select real family and population studies on eye color inheritance.

Parent Eye Colors & Region

Important Notes:
1) These data points reflect actual but limited real-family or population samples. Not all combinations or regions are covered.
2) The presence or absence of data here does not imply impossibility or certainty.
3) For predictive approaches, see advanced SNP-based systems like HIrisPlex-S or consult recent GWAS research.

The Genetics of Eye Color

Eye color inheritance represents one of the most fascinating examples of polygenic traits in human genetics. The complexity of this system demonstrates how multiple genes interact to create the diversity of human eye colors.

Key Gene: HERC2/OCA2

The primary genetic region controlling eye color:

rs12913832: [A/G] → Brown rs12913832: [G/G] → Blue
This SNP accounts for approximately 74% of eye color variation in European populations.

Modifier Genes

Secondary genes that influence final eye color:

  • SLC24A4 – Green color development
  • TYR – Melanin synthesis
  • IRF4 – Melanin regulation

Understanding Inheritance Patterns

Classical vs. Modern Understanding

The old model of simple dominant/recessive inheritance has been replaced by a more nuanced understanding involving:

  • Multiple interacting genes
  • Variable expressivity
  • Environmental influences
  • Complex melanin patterns

Why Predictions Are Complex

Several factors affect inheritance:

  • Gene interactions
  • Recessive alleles
  • Variable penetrance
  • Developmental changes
Modern genetic testing examines multiple SNPs to achieve accurate predictions.

Population Genetics

Eye color distribution varies significantly across populations, reflecting both evolutionary history and selective pressures. This distribution helps us understand human migration patterns and genetic diversity.

European Populations

  • Blue eyes: 40-60%
  • Green eyes: 15-25%
  • Brown eyes: 20-35%

Global Variations

  • East Asian: >95% brown
  • African: >95% brown
  • Mixed populations: Variable

Modern Research Methods

Current genetic research employs sophisticated techniques to understand eye color inheritance:

Analysis Methods

  • Genome-wide association studies (GWAS)
  • Next-generation sequencing
  • Population genetics analysis
  • Machine learning predictions

Key Findings

  • Multiple genes influence final color
  • Complex interaction patterns exist
  • Environmental factors play a role
  • Prediction requires genetic data

CalculateQuick